genetics of testicular germ cell tumors
نویسندگان
چکیده
testicular germ cell tumor (tgct) is the most solid tumor in 20-40 years old man. tgct account for 95% of testicular tumors and represent a unique type of human cancer from several different perspectives. tgct arise by transformation of germ cells. the transformed germ cells exhibit ploripotentially to differentiate into embryonic. extra-embryonic, and somatic tissue types, and are highly sensitive to cisplatin-based chemotherapy. investigation into the genetics of tgct can provide methods of molecular diagnosis and help to the understanding of molecular basis of transformation, differentiation and sensitivity/resistance . the molecular basis for the chemosensitivity of these tumors is poorly understood, although initial stadies suggest that wild-type p53 might play a central role, further studies will provide insights into why other other solid tumors remain far from curable. the following review will provide information about genetic altration and chromosomal aberration occur in tgct. these studies have identified multiplication of 12p, manifested in 1 (12p) or tandem duplication of 12p, as a unique change in tgct which serves as a diagnostic marker. these data also indicate that multiple genetic events play a role in distinct pathways in the development of tgct, and further elucidation of the underlying genetic and biochemical mechanisms is central to unraveling biology and improving treatment of tgct.
منابع مشابه
Molecular genetics of testicular germ cell tumors.
Testicular germ cell tumors (TGCT) are the most common malignancy in young men. While most TGCT are potentially curable, approximately 5% of patients with TGCT may develop chemoresistance and die from the disease. This review article summarizes current knowledge in genetics underlying the development, progression and chemoresistance of TGCT. Most post-pubertal TGCT originate from intratubular g...
متن کاملBilateral testicular germ cell tumors.
Testicular cancer represents 1% to 1.5% of neoplasias in males and 5% of urologic tumors in general. The incidence of bilateral testicular tumors is 1-5%. Approximately one third of the cases are diagnosed as synchronous, while the other two thirds are diagnosed as metachronous tumors. Additionally, 5% of all patients diagnosed with testicular cancer may have contralateral intratubular germ cel...
متن کاملGerm cell origin of testicular carcinoid tumors.
PURPOSE Carcinoids are neuroendocrine tumors and most frequently occur within tissues derived from the embryonic gut. These tumors can occur in any organ site but are rare in the testis. The cell type giving rise to testicular carcinoid is unknown. We hypothesized that testicular carcinoid may have a germ cell origin. EXPERIMENTAL DESIGN We describe our analysis of protein and genetic markers...
متن کاملManagement of recurrent testicular germ cell tumors.
Although front-line chemotherapy cures most men with testicular germ cell tumors, salvage therapy is still important in a small but significant minority. Second-line conventional-dose or high-dose chemotherapy with stem cell rescue may cure 25%-50% of patients. New chemotherapeutic agents, including the taxanes gemcitabine and oxaliplatin, have added to the therapeutic armamentarium. Salvage su...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
journal of reproduction and infertilityجلد ۱، شماره ۱، صفحات ۴۴-۵۲
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023